Colchicine

What is colchicine (Colcrys)?

Colchicine affects the way the body responds to uric acid crystals, which reduces swelling and pain. Generic forms of colchicine have been used to treat or prevent attacks of gout or to treat symptoms of Behcet’s syndrome (such as swelling, redness, warmth, and pain). Colchicine is not a cure for gouty arthritis or Behcet’s syndrome, and it will not prevent these diseases from progressing. Colchicine should not be used as a routine pain medication for other conditions.

Side effects of colchicine

  • muscle pain or weakness;
  • numbness or tingly feeling in your fingers or toes;
  • pale or gray appearance of your lips, tongue, or hands;
  • severe vomiting or diarrhea;
  • easy bruising or bleeding, feeling weak or tired;
  • fever, chills, body aches, flu symptoms;
  • blood in your urine; or
  • urinating less than usual or not at all.

Less serious side effects may include:

  • mild nausea or vomiting, stomach pain; or
  • mild diarrhea.

Prednisone

What is prednisone?

Prednisone is a corticosteroid. It prevents the release of substances in the body that cause inflammation. It also suppresses the immune system.

Prednisone side effects

Get emergency medical help if you have any of these signs of an allergic reaction to prednisone: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • blurred vision, eye pain, or seeing halos around lights;
  • swelling, rapid weight gain, feeling short of breath;
  • severe depression, feelings of extreme happiness or sadness, changes in personality or behavior, seizure (convulsions);
  • bloody or tarry stools, coughing up blood;
  • pancreatitis (severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate);
  • low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling); or
  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

Other common prednisone side effects may include:

  • sleep problems (insomnia), mood changes;
  • increased appetite, gradual weight gain;
  • acne, increased sweating, dry skin, thinning skin, bruising or discoloration;
  • slow wound healing;
  • headache, dizziness, spinning sensation;
  • nausea, stomach pain, bloating; or
  • changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

Allopurinol

What is Allopurinol?

Allopurinol reduces the production of uric acid in your body. Uric acid buildup can lead to gout or kidney stones. Allopurinol is used to treat gout or kidney stones, and to decrease levels of uric acid in people who are receiving cancer treatment.

Allopurinol side effects

Get emergency medical help if you have any of these signs of an allergic reaction to allopurinol: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using allopurinol and call your doctor at once if you have a serious side effect such as:

  • fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
  • the first sign of any skin rash, no matter how mild;
  • pain or bleeding when you urinate;
  • nausea, upper stomach pain, itching, loss of appetite, weight loss, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • urinating less than usual or not at all;
  • joint pain, flu symptoms;
  • severe tingling, numbness, pain, muscle weakness; or
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin.